Phenotypes associated with this allele

• Allele Symbol: Gsdme^em1Fsha
• Allele Name: endonuclease-mediated mutation 1, Feng Shao
• Allele ID: MGI:6196337
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gsdme^em1Fsha/Gsdme^em1Fsha	C57BL/6NCrl-Gsdme^em1Fsha	MGI:6196339

Genotype
MGI:6196339

hm1

• Allelic Composition: Gsdme^em1Fsha/Gsdme^em1Fsha
• Genetic Background: C57BL/6NCrl-Gsdme^em1Fsha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to injury ( J:250434 )

• following cisplatin treatment, mice exhibit protected from tissue damage and weight loss, including reduced spleen weight and lymphocyte numbers, and lung injuries compared with wild-type mice

• following 5-fluorouracil treatment, mice exhibit reduced hemorrhage, inflammatory cell infiltration and loss of crypts in the small intestine compared with wild-type mice

• following bleomycin treatment, mice exhibit reduced lung injury and inflammation compared with wild-type mice

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:250434 )

N • unlike other knock-out mice, hearing is normal