Phenotypes associated with this allele

• Allele Symbol: Dusp14^em1Lyg
• Allele Name: endonuclease-mediated mutation 1, Yi-Gang Li
• Allele ID: MGI:6196886
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dusp14^em1Lyg/Dusp14^em1Lyg	Not Specified	MGI:6197024

Genotype
MGI:6197024

hm1

• Allelic Composition: Dusp14^em1Lyg/Dusp14^em1Lyg
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:263251 )

• 4 weeks after aortic banding

enlarged heart ( J:263251 )

• 4 weeks after aortic banding

myocardium hypertrophy ( J:263251 )

• 4 weeks after aortic banding

increased heart weight ( J:263251 )

• 4 weeks after aortic banding

cardiac fibrosis ( J:263251 )

• 4 weeks after aortic banding with both interstitial and perivascular spaces

decreased cardiac muscle contractility ( J:263251 )

• 4 weeks after aortic banding

increased response of heart to induced stress ( J:263251 )

• 4 weeks after aortic banding, mice exhibit increased myocardial hypertrophy (increased heart weight/bodyweight ratio, heart weight/tibia length ratio, larger gross heart size, cross-sectional area of cardiomyocytes), cardiac fibrosis, left ventricular chamber dimension and lung weight with lower left ventricle fractional shortening and left ventricle ejection fraction compared with wild-type mice

homeostasis/metabolism

increased response of heart to induced stress ( J:263251 )

• 4 weeks after aortic banding, mice exhibit increased myocardial hypertrophy (increased heart weight/bodyweight ratio, heart weight/tibia length ratio, larger gross heart size, cross-sectional area of cardiomyocytes), cardiac fibrosis, left ventricular chamber dimension and lung weight with lower left ventricle fractional shortening and left ventricle ejection fraction compared with wild-type mice

muscle

increased myocardial fiber size ( J:263251 )

• 4 weeks after aortic banding

myocardium hypertrophy ( J:263251 )

• 4 weeks after aortic banding

decreased cardiac muscle contractility ( J:263251 )

• 4 weeks after aortic banding

respiratory system

increased lung weight ( J:263251 )

• 4 weeks after aortic banding

growth/size/body

enlarged heart ( J:263251 )

• 4 weeks after aortic banding

myocardium hypertrophy ( J:263251 )

• 4 weeks after aortic banding

increased heart weight ( J:263251 )

• 4 weeks after aortic banding

increased lung weight ( J:263251 )

• 4 weeks after aortic banding