About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-cat,-Dusp14)4Lyg
transgene insertion 4, Yi-Gang Li
MGI:6197022
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(CAG-cat,-Dusp14)4Lyg/0
involves: C57BL/6J * FVB/N MGI:6197025


Genotype
MGI:6197025
cn1
Allelic
Composition
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(CAG-cat,-Dusp14)4Lyg/0
Genetic
Background
involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Tg(CAG-cat,-Dusp14)4Lyg mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 4 weeks after aortic banding but less severe than in control mice
• 4 weeks after aortic banding but less severe than in control mice
• 4 weeks after aortic banding but less severe than in control mice
• 4 weeks after aortic banding but less severe than in control mice
• 4 weeks after aortic banding with both interstitial and perivascular spaces but less severe than in control mice
• 4 weeks after aortic banding but less severe than in control mice
• after aortic banding, mice exhibit less cardiac hypertrophic response (lower heart and liver weight, smaller heart and smaller cardiomyocytes size) and reduced fibrosis and fractional shortening and ejection fraction compared with wild-type mice

muscle
• 4 weeks after aortic banding but less severe than in control mice
• 4 weeks after aortic banding but less severe than in control mice
• 4 weeks after aortic banding but less severe than in control mice

homeostasis/metabolism
• after aortic banding, mice exhibit less cardiac hypertrophic response (lower heart and liver weight, smaller heart and smaller cardiomyocytes size) and reduced fibrosis and fractional shortening and ejection fraction compared with wild-type mice

respiratory system
• 4 weeks after aortic banding but less severe than in control mice

growth/size/body
• 4 weeks after aortic banding but less severe than in control mice
• 4 weeks after aortic banding but less severe than in control mice
• 4 weeks after aortic banding but less severe than in control mice
• 4 weeks after aortic banding but less severe than in control mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory