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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nap1l1em1Jwji
endonuclease-mediated mutation 1, Jianwei Jiao
MGI:6197066
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nap1l1em1Jwji/Nap1l1em1Jwji Not Specified MGI:6197246


Genotype
MGI:6197246
hm1
Allelic
Composition		 Nap1l1em1Jwji/Nap1l1em1Jwji
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nap1l1em1Jwji mutation (0 available); any Nap1l1 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:263406 )
• fewer than expected mice are born

nervous system
decreased neuronal precursor proliferation ( J:263406 )
• at E16.5 in the ventricular zone and subventricular zone
abnormal neurite morphology ( J:263406 )
• neurons exhibit excessive process growth compared with wild-type cells
abnormal glial cell physiology ( J:263406 )
• reduced radial glia cell proliferation isolated from E12 embryos
• increased Tuj1+ cells in E15 brain sections
• however, transgenic overexpression restores cell distribution

cellular
decreased neuronal precursor proliferation ( J:263406 )
• at E16.5 in the ventricular zone and subventricular zone




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory