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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mazem#Mhll
endonuclease-mediated mutation, Meade Haller
MGI:6197212
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mazem#Mhll/Mazem#Mhll C57BL/6J-Mazem#Mhll MGI:6197239
ht2
 		Mazem#Mhll/Maz+ C57BL/6J-Mazem#Mhll MGI:6197240


Genotype
MGI:6197239
hm1
Allelic
Composition		 Mazem#Mhll/Mazem#Mhll
Genetic
Background		 C57BL/6J-Mazem#Mhll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mazem#Mhll mutation (0 available); any Maz mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:257647 )
• fewer than expected mice are present at E16.5 and E18.5
postnatal lethality, incomplete penetrance ( J:257647 )
• further lethality is observed by P13

reproductive system
male infertility ( J:257647 )
• in the surviving male mouse despite normal testis and epididymal morphology

renal/urinary system
renal hypoplasia ( J:257647 )
• in the surviving mouse
absent kidney ( J:257647 )
• in some mice
single kidney ( J:257647 )
• in the surviving male mouse despite normal ureter development

cardiovascular system
abnormal heart atrium morphology ( J:257647 )
• mismatched atrial size in the surviving male mouse despite normal heart size
• however, no obstructions are observed

growth/size/body
fetal growth retardation ( J:257647 )
• slight




Genotype
MGI:6197240
ht2
Allelic
Composition		 Mazem#Mhll/Maz+
Genetic
Background		 C57BL/6J-Mazem#Mhll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mazem#Mhll mutation (0 available); any Maz mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:257647 )
• fewer than expected mice are present at E16.5 and E18.5

renal/urinary system
urinary bladder hypoplasia ( J:257647 )
• modestly with altered architecture
abnormal bladder urine volume ( J:257647 )
• following methylene blue dye injection, mice exhibit abrogated bladder capacity compared with wild-type mice
• however, the mouse did not exhibit increased VUR, cryptochisim or overt penile malformation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory