All Phenotypes Tyro3<m1> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tyro3^m1
mutation 1
MGI:6197245

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	anx/anx Tyro3^m1/Tyro3^m1	involves: C3HeB/FeJLe * C57BL/6J	MGI:6284561
cx2	anx/anx Tg(Tyro3-GFP)1Sapc/? Tyro3^m1/Tyro3^m1	involves: C3HeB/FeJLe * C57BL/6J	MGI:6287219
cx3	anx/anx Tg(Tyro3*-Gfp)1Sapc/? Tyro3^m1/Tyro3^m1	involves: C3HeB/FeJLe * C57BL/6J	MGI:6287394
cx4	anx/anx Tg(TYRO3)1Sapc/? Tyro3^m1/Tyro3^m1	involves: C3HeB/FeJLe * C57BL/6J	MGI:6287398

Allelic Composition	anx/anx Tyro3^m1/Tyro3^m1
Genetic Background	involves: C3HeB/FeJLe * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
anx mutation (1 available); any anx mutation (1 available)
Tyro3^m1 mutation (4 available); any Tyro3 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

cachexia ( J:241666 )

nervous system

abnormal hypothalamus morphology ( J:241666 )

• at 19 days of age only 20.2% of normal levels of Npy+ soma are present in the arcuate nucleus, the Npy+ cell bodies are clustered aberrantly within and adjacent to the median eminence, and lack Npy+ processes that normally extend towards and into the paraventricular nucleus or dorsomedial nucleus of the hypothalamus

hematopoietic system

abnormal platelet morphology ( J:241666 )

• platelets from homozygotes appear smaller and 17.5% contain large vacuoles, although electron microscopy shows only normal morphology and numbers of dense and alpha granules

abnormal platelet activation ( J:241666 )

• after activation with thrombin, platelets from homozygotes have decreased levels of P-selectin on the surface compared with heterozgyous or wildtype controls

homeostasis/metabolism

abnormal platelet activation ( J:241666 )

• after activation with thrombin, platelets from homozygotes have decreased levels of P-selectin on the surface compared with heterozgyous or wildtype controls

Allelic Composition	anx/anx Tg(Tyro3-GFP)1Sapc/? Tyro3^m1/Tyro3^m1
Genetic Background	involves: C3HeB/FeJLe * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
anx mutation (1 available); any anx mutation (1 available)
Tg(Tyro3-GFP)1Sapc mutation (0 available)
Tyro3^m1 mutation (4 available); any Tyro3 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal body weight ( J:241666 )

• relative to anx homozygotes lacking the Tyro3 wildtype transgene, these mice show a partial rescue of phenotype with the body weight at 21 days of age 83.5% increased on average

mortality/aging

abnormal survival ( J:241666 )

• wildtype mouse Tyro3 partially rescues the anx homozygous phenotype, with anx homozygotes still dying prematurely, but surviving past 35 days of age, having 83.58% of Npy+ soma retained in and properly distributed in the arcuate nucleus at 19 days of age, and showing no or only mild behavioural phentoypes of headweaving, ataxia, or tremors

Allelic Composition	anx/anx Tg(Tyro3*-Gfp)1Sapc/? Tyro3^m1/Tyro3^m1
Genetic Background	involves: C3HeB/FeJLe * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
anx mutation (1 available); any anx mutation (1 available)
Tg(Tyro3*-Gfp)1Sapc mutation (0 available)
Tyro3^m1 mutation (4 available); any Tyro3 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

tremors ( J:241666 )

abnormal head movements ( J:241666 )

mortality/aging

premature death ( J:241666 )

growth/size/body

cachexia ( J:241666 )

• unlike wildtype Tyro3, transgenic expression of this R7W point mutant transgene fails to resuce the anx homozygous phenotype, specifically cachexia, death by 21 days of age, and behavioral phenotypes such as head tossing and tremors

Allelic Composition	anx/anx Tg(TYRO3)1Sapc/? Tyro3^m1/Tyro3^m1
Genetic Background	involves: C3HeB/FeJLe * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
anx mutation (1 available); any anx mutation (1 available)
Tg(TYRO3)1Sapc mutation (0 available)
Tyro3^m1 mutation (4 available); any Tyro3 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal body weight ( J:241666 )

• relative to anx homozygotes lacking the TYRO3 human wildtype transgene, these mice show a partial rescue of the anorexia phenotype with the body weight at 21 days of age 92.8% increased on average

mortality/aging

abnormal survival ( J:241666 )

• wildtype human TYRO3 partially rescues the anx homozygous phenotype, with anx homozygotes still dying prematurely, but surviving past 35 days of age and showing no or only mild behavioural phentoypes of headweaving, ataxia, or tremors

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