All Phenotypes Ankrd16<tm1.1Slac> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ankrd16^tm1.1Slac
targeted mutation 1.1, Susan L Ackerman
MGI:6197500

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ankrd16^tm1.1Slac/Ankrd16^tm1.1Slac	B6.129(FVB)-Ankrd16^tm1.1Slac	MGI:6197723
cn2	Ankrd16^tm1.1Slac/Ankrd16^tm1.2Slac Tg(Pcp2-cre)2Mpin/0	B6.129-Ankrd16^tm1.1Slac/Ankrd16^tm1.2Slac Tg(Pcp2-cre)2Mpin	MGI:6197725
cn3	Ankrd16^tm1.1Slac/Ankrd16^tm1.2Slac En1^tm2(cre)Wrst/En1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6197726
cx4	Aars1^sti/Aars1^sti Ankrd16^tm1.1Slac/Ankrd16^tm1.1Slac	B6.Cg-Ankrd16^tm1.1Slac Aars1^sti	MGI:6197721

Allelic Composition	Ankrd16^tm1.1Slac/Ankrd16^tm1.1Slac
Genetic Background	B6.129(FVB)-Ankrd16^tm1.1Slac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd16^tm1.1Slac mutation (0 available); any Ankrd16 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:262421 )

• no obvious pathologies in the brain or other organs, even when aged to 12 months

Allelic Composition	Ankrd16^tm1.1Slac/Ankrd16^tm1.2Slac Tg(Pcp2-cre)2Mpin/0
Genetic Background	B6.129-Ankrd16^tm1.1Slac/Ankrd16^tm1.2Slac Tg(Pcp2-cre)2Mpin

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd16^tm1.1Slac mutation (0 available); any Ankrd16 mutation (25 available)
Ankrd16^tm1.2Slac mutation (0 available); any Ankrd16 mutation (25 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

Purkinje cell degeneration ( J:262421 )

• beginning at 3 weeks of age with the majority of cells absent at 4 weeks of age and no Purkinje cells by 7 months

decreased Purkinje cell number ( J:262421 )

• absent by 7 months

Allelic Composition	Ankrd16^tm1.1Slac/Ankrd16^tm1.2Slac En1^tm2(cre)Wrst/En1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

neuron degeneration ( J:262421 )

• of interneurons in the molecular layer and neurons in the granule cell layer with protein aggregates

• of postnatal cortical and hippocampal neurons

Purkinje cell degeneration ( J:262421 )

• with protein aggregates

Allelic Composition	Aars1^sti/Aars1^sti Ankrd16^tm1.1Slac/Ankrd16^tm1.1Slac
Genetic Background	B6.Cg-Ankrd16^tm1.1Slac Aars1^sti

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aars1^sti mutation (1 available); any Aars1 mutation (69 available)
Ankrd16^tm1.1Slac mutation (0 available); any Ankrd16 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:262421 )

• fewer than expected mice are present at E8.5 and E9.5 with no mice at E10.5

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