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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ankrd16tm1.2Slac
targeted mutation 1.2, Susan L Ackerman
MGI:6197501
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ankrd16tm1.1Slac/Ankrd16tm1.2Slac
Tg(Pcp2-cre)2Mpin/0 		B6.129-Ankrd16tm1.1Slac/Ankrd16tm1.2Slac Tg(Pcp2-cre)2Mpin MGI:6197725
cn2
 		Ankrd16tm1.1Slac/Ankrd16tm1.2Slac
En1tm2(cre)Wrst/En1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6197726


Genotype
MGI:6197725
cn1
Allelic
Composition		 Ankrd16tm1.1Slac/Ankrd16tm1.2Slac
Tg(Pcp2-cre)2Mpin/0
Genetic
Background		 B6.129-Ankrd16tm1.1Slac/Ankrd16tm1.2Slac Tg(Pcp2-cre)2Mpin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd16tm1.1Slac mutation (0 available); any Ankrd16 mutation (25 available)
Ankrd16tm1.2Slac mutation (0 available); any Ankrd16 mutation (25 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
Purkinje cell degeneration ( J:262421 )
• beginning at 3 weeks of age with the majority of cells absent at 4 weeks of age and no Purkinje cells by 7 months
decreased Purkinje cell number ( J:262421 )
• absent by 7 months




Genotype
MGI:6197726
cn2
Allelic
Composition		 Ankrd16tm1.1Slac/Ankrd16tm1.2Slac
En1tm2(cre)Wrst/En1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd16tm1.1Slac mutation (0 available); any Ankrd16 mutation (25 available)
Ankrd16tm1.2Slac mutation (0 available); any Ankrd16 mutation (25 available)
En1tm2(cre)Wrst mutation (1 available); any En1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
neuron degeneration ( J:262421 )
• of interneurons in the molecular layer and neurons in the granule cell layer with protein aggregates
• of postnatal cortical and hippocampal neurons
Purkinje cell degeneration ( J:262421 )
• with protein aggregates




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory