Phenotypes associated with this allele

• Allele Symbol: Rab10^tm1Tax
• Allele Name: targeted mutation 1, Tao Xu
• Allele ID: MGI:6197683
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rab10^tm1Tax/Rab10^tm1Tax	B6.Cg-Rab10^tm1Tax	MGI:6197686

Genotype
MGI:6197686

hm1

• Allelic Composition: Rab10^tm1Tax/Rab10^tm1Tax
• Genetic Background: B6.Cg-Rab10^tm1Tax

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:262459 )

• all mice are resorbed by E9.5

embryo

abnormal germ layer development ( J:262459 )

• germ layer development is largely arrested at E7.5

embryonic growth arrest ( J:262459 )

• embryo degeneration at E8.5

decreased embryo size ( J:262459 )

• at E7.5

failure of primitive streak formation ( J:262459 )

abnormal extraembryonic tissue morphology ( J:262459 )

• yolk sac degradation at E8.5

absent amniotic cavity ( J:262459 )

absent ectoplacental cavity ( J:262459 )

absent extraembryonic coelom ( J:262459 )

abnormal extraembryonic ectoderm morphology ( J:262459 )

• disorganized at E7.5

cellular

abnormal cell nucleus morphology ( J:262459 )

• reduced diameter in embryos

abnormal vacuole morphology ( J:262459 )

• increased vacuole size in embryos

decreased cell proliferation ( J:262459 )

• in E7.5 embryos without an increase in apoptosis

growth/size/body

decreased embryo size ( J:262459 )

• at E7.5