Phenotypes associated with this allele

• Allele Symbol: Trem2^em1Gela
• Allele Name: endonuclease-mediated mutation 1, Gary E Landreth
• Allele ID: MGI:6198553
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0 Trem2^em1Gela/Trem2^+	involves: C57BL/6J	MGI:6198554

Genotype
MGI:6198554

cx1

• Allelic Composition: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0; Trem2^em1Gela/Trem2⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased myeloid cell number ( J:264653 )

• mice show a reduction in the number of plaque-associated myeloid cells compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating an impairment in myeloid cell accumulation around plaques

abnormal hematopoietic system physiology ( J:264653 )

• proliferation of myeloid cells is reduced compared to levels in single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism

amyloid beta deposits ( J:264653 )

• mice show a 31% and 36% reduction in compact fibrillary, thioflavin S positive plaque number and percent area, respectively, in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating altered plaque structure

• however, the total number of cortical plaques and percent area is similar to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

• mice show a decrease in soluble amyloid beta 1-40 in the cortex and thus an increased ratio of amyloid beta 42/40 compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

nervous system

amyloid beta deposits ( J:264653 )

• mice show a 31% and 36% reduction in compact fibrillary, thioflavin S positive plaque number and percent area, respectively, in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating altered plaque structure

• however, the total number of cortical plaques and percent area is similar to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

• mice show a decrease in soluble amyloid beta 1-40 in the cortex and thus an increased ratio of amyloid beta 42/40 compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

abnormal neurite morphology ( J:264653 )

• marker analysis indicates increased plaque-associated neuritic dystrophy compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice