Phenotypes associated with this allele

• Allele Symbol: Ggcx^tm1.1Kry
• Allele Name: targeted mutation 1.1, Gerard Karsenty
• Allele ID: MGI:6198558
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bglap/Bglap2^tm1Kry/Bglap^+ Ggcx^tm1.1Kry/Ggcx^tm1.1Kry Tg(BGLAP-cre)1Clem/0	involves: 129S7/SvEvBrd * FVB/NJ	MGI:6198739
cn2	Bglap/Bglap2^tm1Kry/Bglap2^+ Ggcx^tm1.1Kry/Ggcx^tm1.1Kry Tg(BGLAP-cre)1Clem/0	involves: 129S7/SvEvBrd * FVB/NJ	MGI:6198741
cn3	Ggcx^tm1.1Kry/Ggcx^tm1.1Kry Tg(Col1a1-cre)1Kry/0	involves: FVB/N	MGI:6198735
cn4	Ggcx^tm1.1Kry/Ggcx^tm1.1Kry Tg(BGLAP-cre)1Clem/0	involves: FVB/NJ	MGI:6198737

Genotype
MGI:6198739

cn1

• Allelic Composition: Bglap/Bglap2^tm1Kry/Bglap⁺; Ggcx^tm1.1Kry/Ggcx^tm1.1Kry; Tg(BGLAP-cre)1Clem/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:264734 )

N • glucose tolerance is normal

Genotype
MGI:6198741

cn2

• Allelic Composition: Bglap/Bglap2^tm1Kry/Bglap2⁺; Ggcx^tm1.1Kry/Ggcx^tm1.1Kry; Tg(BGLAP-cre)1Clem/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB/NJ

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:264734 )

N • glucose tolerance is normal

Genotype
MGI:6198735

cn3

• Allelic Composition: Ggcx^tm1.1Kry/Ggcx^tm1.1Kry; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: FVB/N

reproductive system

reproductive system phenotype ( J:264734 )

N • mice do not exhibit hypergonadism with normal sperm count, testis weight, epididymis weight, and seminal vesicle weight

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:264734 )

• when fed a high-fat diet

hypoglycemia ( J:264734 )

• in fasted mice fed a high-fat diet

abnormal circulating osteocalcin level ( J:264734 )

• increased levels of GLU-OCN 3 to 4 times

• however, total and GLA-OCN levels are normal

increased carbon dioxide production ( J:264734 )

increased oxygen consumption ( J:264734 )

improved glucose tolerance ( J:264734 )

• in female and male mice when fed a high-fat diet or a normal diet

increased insulin sensitivity ( J:264734 )

• in female and male mice when fed a high-fat diet or a normal diet

• however, hyperinsulinemia when fed a high-fat diet is normal

growth/size/body

decreased susceptibility to diet-induced obesity ( J:264734 )

• when fed a high-fat diet

thin body ( J:264734 )

adipose tissue

decreased epididymal fat pad weight ( J:264734 )

Genotype
MGI:6198737

cn4

• Allelic Composition: Ggcx^tm1.1Kry/Ggcx^tm1.1Kry; Tg(BGLAP-cre)1Clem/0
• Genetic Background: involves: FVB/NJ

reproductive system

reproductive system phenotype ( J:264734 )

N • mice do not exhibit hypergonadism with normal sperm count, testis weight, epididymis weight, and seminal vesicle weight

homeostasis/metabolism

decreased circulating osteocalcin level ( J:264734 )

• GLA-OCN and total OCN levels decreased 75 and 10 times, respectively

improved glucose tolerance ( J:264734 )

skeleton

skeleton phenotype ( J:264734 )

N • mice exhibit normal trabecular and cortical bone density, numbers of osteoblast and osteoblasts, bone formation rates and osteoclastic activity