About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vkorc1tm1.1Kry
targeted mutation 1.1, Gerard Karsenty
MGI:6198560
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Vkorc1tm1.1Kry/Vkorc1tm1.1Kry
Tg(BGLAP-cre)1Clem/0 		involves: FVB/NJ MGI:6198744
cn2
 		Vkorc1tm1.1Kry/Vkorc1tm1.1Kry
Vkorc1l1tm1.1Kry/Vkorc1l1tm1.1Kry
Tg(BGLAP-cre)1Clem/0 		involves: FVB/NJ MGI:6198758


Genotype
MGI:6198744
cn1
Allelic
Composition		 Vkorc1tm1.1Kry/Vkorc1tm1.1Kry
Tg(BGLAP-cre)1Clem/0
Genetic
Background		 involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BGLAP-cre)1Clem mutation (1 available)
Vkorc1tm1.1Kry mutation (0 available); any Vkorc1 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:264734 )
N
• slight but not significant improvement in glucose tolerance
abnormal circulating osteocalcin level ( J:264734 )
• decreased GLA-OCN, further upon prevention of coprophagy
• 10-fold increase in GLU-OCN levels
• however, total OCN levels are normal

hematopoietic system
hematopoietic system phenotype ( J:264734 )
N
• unlike in null mice, no hemostatic defects were detected




Genotype
MGI:6198758
cn2
Allelic
Composition		 Vkorc1tm1.1Kry/Vkorc1tm1.1Kry
Vkorc1l1tm1.1Kry/Vkorc1l1tm1.1Kry
Tg(BGLAP-cre)1Clem/0
Genetic
Background		 involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BGLAP-cre)1Clem mutation (1 available)
Vkorc1l1tm1.1Kry mutation (0 available); any Vkorc1l1 mutation (22 available)
Vkorc1tm1.1Kry mutation (0 available); any Vkorc1 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal circulating osteocalcin level ( J:264734 )
• increase in GLU-OCN levels as in mice with wild-type Vkorc1l1




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory