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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		conls
coneless
MGI:6198566
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		conls/conls Cnbc:NMRI-conls MGI:6198572


Genotype
MGI:6198572
hm1
Allelic
Composition		 conls/conls
Genetic
Background		 Cnbc:NMRI-conls
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
conls mutation (1 available); any conls mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased retina cone cell number ( J:82809 )
• histologic/immunohistochemical analysis reveals the presence of fewer cones in eyes of homozyogous mutant than in wild-type control mice

pigmentation
abnormal retina pigment epithelium morphology ( J:82809 )
• drusen and aggregates are observed in RPE of homozygous mutant mice

vision/eye
decreased retina cone cell number ( J:82809 )
• histologic/immunohistochemical analysis reveals the presence of fewer cones in eyes of homozyogous mutant than in wild-type control mice
abnormal retina pigment epithelium morphology ( J:82809 )
• drusen and aggregates are observed in RPE of homozygous mutant mice
abnormal cone electrophysiology ( J:82809 )
• homozygous mutant mice exhibit little or no cone-derived electroretinographic (ERG) signal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory