All Phenotypes Plcg2<M3Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Plcg2^M3Btlr
mutation 3, Bruce Beutler
MGI:6199511

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plcg2^M3Btlr/Plcg2^M3Btlr	C57BL/6J-Plcg2^M3Btlr	MGI:6199513

Allelic Composition	Plcg2^M3Btlr/Plcg2^M3Btlr
Genetic Background	C57BL/6J-Plcg2^M3Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2^M3Btlr mutation (0 available); any Plcg2 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B-1a cell number ( J:265101 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

decreased IgM level ( J:265101 )

immune system

decreased B-1a cell number ( J:265101 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

abnormal humoral immune response ( J:265101 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

decreased IgM level ( J:265101 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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