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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc5a2m2Btlr
mutation 2, Bruce Beutler
MGI:6199601
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc5a2m2Btlr/Slc5a2m2Btlr C57BL/6J-Slc5a2m2Btlr MGI:6199602


Genotype
MGI:6199602
hm1
Allelic
Composition		 Slc5a2m2Btlr/Slc5a2m2Btlr
Genetic
Background		 C57BL/6J-Slc5a2m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc5a2m2Btlr mutation (0 available); any Slc5a2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to induced colitis ( J:265117 )
• susceptibility to dextran sodium sulfate (DSS)-induced colitis at 10 days post-DSS treatment
increased tumor necrosis factor secretion ( J:265117 )
• increased TNF secretion in response to TLR9 ligand, CpG (primed with IFN)

growth/size/body
increased body weight ( J:265117 )

digestive/alimentary system
increased susceptibility to induced colitis ( J:265117 )
• susceptibility to dextran sodium sulfate (DSS)-induced colitis at 10 days post-DSS treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory