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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgb2m3Btlr
mutation 3, Bruce Beutler
MGI:6199655
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itgb2m3Btlr/Itgb2m3Btlr C57BL/6J-Itgb2m3Btlr MGI:6199657


Genotype
MGI:6199657
hm1
Allelic
Composition		 Itgb2m3Btlr/Itgb2m3Btlr
Genetic
Background		 C57BL/6J-Itgb2m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb2m3Btlr mutation (0 available); any Itgb2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:265126 )
• total B cell, IgM+ B cell, and IgD+ B cell number in the peripheral blood
increased IgE level ( J:265126 )
• in the serum

immune system
decreased B cell number ( J:265126 )
• total B cell, IgM+ B cell, and IgD+ B cell number in the peripheral blood
increased IgE level ( J:265126 )
• in the serum
impaired humoral immune response ( J:265126 )
• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory