Phenotypes associated with this allele

• Allele Symbol: Vav1^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:6199670
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vav1^m1Btlr/Vav1^m1Btlr	C57BL/6J-Vav1^m1Btlr	MGI:6199672

Genotype
MGI:6199672

hm1

• Allelic Composition: Vav1^m1Btlr/Vav1^m1Btlr
• Genetic Background: C57BL/6J-Vav1^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B-1 B cell number ( J:265128 )

increased central memory CD4-positive, alpha-beta T cell number ( J:265128 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:265128 )

increased central memory CD8 positive, alpha-beta T cell number ( J:265128 )

decreased CD8-positive, naive alpha-beta T cell number ( J:265128 )

decreased T cell number ( J:265128 )

decreased CD4-positive, alpha-beta T cell number ( J:265128 )

decreased CD8-positive, alpha-beta T cell number ( J:265128 )

decreased single-positive T cell number ( J:265128 )

decreased IgD level ( J:265128 )

• on peripheral B cells

decreased IgG level ( J:265128 )

increased IgM level ( J:265128 )

• on peripheral B cells

immune system

decreased B-1 B cell number ( J:265128 )

increased central memory CD4-positive, alpha-beta T cell number ( J:265128 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:265128 )

increased central memory CD8 positive, alpha-beta T cell number ( J:265128 )

decreased CD8-positive, naive alpha-beta T cell number ( J:265128 )

decreased T cell number ( J:265128 )

decreased CD4-positive, alpha-beta T cell number ( J:265128 )

decreased CD8-positive, alpha-beta T cell number ( J:265128 )

decreased single-positive T cell number ( J:265128 )

abnormal humoral immune response ( J:265128 )

decreased IgD level ( J:265128 )

• on peripheral B cells

decreased IgG level ( J:265128 )

increased IgM level ( J:265128 )

• on peripheral B cells