About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkcdm2Btlr
mutation 2, Bruce Beutler
MGI:6199966
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prkcdm2Btlr/Prkcdm2Btlr C57BL/6J-Prkcdm2Btlr MGI:6199968


Genotype
MGI:6199968
hm1
Allelic
Composition		 Prkcdm2Btlr/Prkcdm2Btlr
Genetic
Background		 C57BL/6J-Prkcdm2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcdm2Btlr mutation (0 available); any Prkcd mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to induced colitis ( J:265146 )
• increased susceptibility to DSS-induced colitis on days 7 and 10 post-DSS treatment
increased IgM level ( J:265146 )
• increased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
enhanced humoral immune response ( J:265146 )
• increased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

digestive/alimentary system
increased susceptibility to induced colitis ( J:265146 )
• increased susceptibility to DSS-induced colitis on days 7 and 10 post-DSS treatment

hematopoietic system
increased IgM level ( J:265146 )
• increased T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory