Phenotypes associated with this allele

• Allele Symbol: Tg^m3Btlr
• Allele Name: mutation 3, Bruce Beutler
• Allele ID: MGI:6200223
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tg^m3Btlr/Tg^m3Btlr	C57BL/6J-Tg^m3Btlr	MGI:6201307
hm2	Tg^m3Btlr/Tg^m3Btlr	C57BL/6J-Tg^m3Btlr/Btlr	MGI:6761464

Genotype
MGI:6201307

hm1

• Allelic Composition: Tg^m3Btlr/Tg^m3Btlr
• Genetic Background: C57BL/6J-Tg^m3Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased body fat mass ( J:265197 )

digestive/alimentary system

increased susceptibility to induced colitis ( J:265197 )

• dextran sulfate sodium (DSS)-induced colitis on days 7 and 10 after DSS treatment

growth/size/body

decreased body fat mass ( J:265197 )

decreased lean body mass ( J:265197 )

decreased body weight ( J:265197 )

hematopoietic system

decreased B cell number ( J:265197 )

decreased IgE level ( J:265197 )

immune system

increased susceptibility to induced colitis ( J:265197 )

• dextran sulfate sodium (DSS)-induced colitis on days 7 and 10 after DSS treatment

decreased B cell number ( J:265197 )

decreased IgE level ( J:265197 )

limbs/digits/tail

short femur ( J:265197 )

short tibia ( J:265197 )

skeleton

short femur ( J:265197 )

short tibia ( J:265197 )

abnormal pelvic girdle bone morphology ( J:265197 )

• reduced lengths of pelvises

Genotype
MGI:6761464

hm2

• Allelic Composition: Tg^m3Btlr/Tg^m3Btlr
• Genetic Background: C57BL/6J-Tg^m3Btlr/Btlr

growth/size/body

decreased body size ( J:309727 )