About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mlh1m2Btlr
mutation 2, Bruce Beutler
MGI:6200239
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mlh1m2Btlr/Mlh1m2Btlr C57BL/6J-Mlh1m2Btlr MGI:6200241


Genotype
MGI:6200241
hm1
Allelic
Composition		 Mlh1m2Btlr/Mlh1m2Btlr
Genetic
Background		 C57BL/6J-Mlh1m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlh1m2Btlr mutation (0 available); any Mlh1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgE level ( J:265207 )
• total IgE in the serum
increased IgM level ( J:265207 )
• diminished T-dependent antibody responses to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

immune system
abnormal humoral immune response ( J:265207 )
• diminished T-dependent antibody responses to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgE level ( J:265207 )
• total IgE in the serum
increased IgM level ( J:265207 )
• diminished T-dependent antibody responses to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory