Phenotypes associated with this allele

• Allele Symbol: Stk4^m2Btlr
• Allele Name: mutation 2, Bruce Beutler
• Allele ID: MGI:6200290
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk4^m2Btlr/Stk4^m2Btlr	C57BL/6J-Stk4^m2Btlr	MGI:6200292

Genotype
MGI:6200292

hm1

• Allelic Composition: Stk4^m2Btlr/Stk4^m2Btlr
• Genetic Background: C57BL/6J-Stk4^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased neutrophil cell number ( J:265237 )

increased dendritic cell number ( J:265237 )

decreased B-1 B cell number ( J:265237 )

decreased B-2 B cell number ( J:265237 )

increased B-1b cell number ( J:265237 )

increased NK cell number ( J:265237 )

increased central memory CD4-positive, alpha-beta T cell number ( J:265237 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:265237 )

increased central memory CD8 positive, alpha-beta T cell number ( J:265237 )

increased effector memory CD8-positive, alpha-beta T cell number ( J:265237 )

decreased CD8-positive, naive alpha-beta T cell number ( J:265237 )

decreased T cell number ( J:265237 )

decreased CD4-positive, alpha-beta T cell number ( J:265237 )

decreased CD8-positive, alpha-beta T cell number ( J:265237 )

decreased single-positive T cell number ( J:265237 )

increased macrophage cell number ( J:265237 )

decreased IgD level ( J:265237 )

increased IgE level ( J:265237 )

• in the serum

immune system

increased neutrophil cell number ( J:265237 )

increased dendritic cell number ( J:265237 )

decreased B-1 B cell number ( J:265237 )

decreased B-2 B cell number ( J:265237 )

increased B-1b cell number ( J:265237 )

increased NK cell number ( J:265237 )

increased central memory CD4-positive, alpha-beta T cell number ( J:265237 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:265237 )

increased central memory CD8 positive, alpha-beta T cell number ( J:265237 )

increased effector memory CD8-positive, alpha-beta T cell number ( J:265237 )

decreased CD8-positive, naive alpha-beta T cell number ( J:265237 )

decreased T cell number ( J:265237 )

decreased CD4-positive, alpha-beta T cell number ( J:265237 )

decreased CD8-positive, alpha-beta T cell number ( J:265237 )

decreased single-positive T cell number ( J:265237 )

increased macrophage cell number ( J:265237 )

decreased IgD level ( J:265237 )

increased IgE level ( J:265237 )

• in the serum