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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ly96m1Btlr
mutation 1, Bruce Beutler
MGI:6200370
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ly96m1Btlr/Ly96m1Btlr C57BL/6J-Ly96m1Btlr MGI:6200372


Genotype
MGI:6200372
hm1
Allelic
Composition		 Ly96m1Btlr/Ly96m1Btlr
Genetic
Background		 C57BL/6J-Ly96m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ly96m1Btlr mutation (0 available); any Ly96 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage apoptosis ( J:265259 )
• decrease in LPS-induced macrophage necroptosis
decreased interleukin-1 beta secretion ( J:265259 )
• peritoneal macrophages isolated from pique homozygous mice secreted reduced amounts of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed bynigericin treatment
decreased tumor necrosis factor secretion ( J:265259 )
• from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

cellular
decreased macrophage apoptosis ( J:265259 )
• decrease in LPS-induced macrophage necroptosis

hematopoietic system
decreased macrophage apoptosis ( J:265259 )
• decrease in LPS-induced macrophage necroptosis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory