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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pi4kam1Btlr
mutation 1, Bruce Beutler
MGI:6200379
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pi4kam1Btlr/Pi4kam1Btlr C57BL/6J-Pi4kam1Btlr MGI:6200381


Genotype
MGI:6200381
hm1
Allelic
Composition		 Pi4kam1Btlr/Pi4kam1Btlr
Genetic
Background		 C57BL/6J-Pi4kam1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pi4kam1Btlr mutation (0 available); any Pi4ka mutation (126 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage apoptosis ( J:265261 )
• decrease in LPS-induced necroptosis
increased interleukin-1 beta secretion ( J:265261 )
• increased inflammatory responses related to increased secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed bynigericin treatment
decreased tumor necrosis factor secretion ( J:265261 )
• reduced TNFalpha secretion in response to the TLR1/2 ligand PAM3CSK4

cellular
decreased macrophage apoptosis ( J:265261 )
• decrease in LPS-induced necroptosis
increased cell death ( J:265261 )
• reduced MTT values of peritoneal exudate cells

hematopoietic system
decreased macrophage apoptosis ( J:265261 )
• decrease in LPS-induced necroptosis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory