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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spatc1lem1Choc
endonuclease-mediated mutation 1, Chunghee Cho
MGI:6200789
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spatc1lem1Choc/Spatc1lem1Choc involves: C57BL/6J * C57BL/6N MGI:6200790
ht2
 		Spatc1lem1Choc/Spatc1l+ involves: C57BL/6J * C57BL/6N MGI:6200791


Genotype
MGI:6200790
hm1
Allelic
Composition		 Spatc1lem1Choc/Spatc1lem1Choc
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spatc1lem1Choc mutation (0 available); any Spatc1l mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:265193 )
N
• females are fertile
• no significant difference in testis size or testis to body weight ratio, normal appearance and weight of the epididymis, no disruptions in seminiferous tubules
teratozoospermia ( J:265193 )
• detached heads are seen in most cauda epididymal sperm
• no intact sperm are seen in the cauda epididymis but some normal testicular sperm are seen
detached sperm flagellum ( J:265193 )
• ~79% of headless flagella from the cauda epididymis display weak motility
• the capitulum and segmented column are found in the separated tail while the basal plate remains attached to the head
male infertility ( J:265193 )
• males produce vaginal plugs but no offspring in crosses with wild-type females

cellular
teratozoospermia ( J:265193 )
• detached heads are seen in most cauda epididymal sperm
• no intact sperm are seen in the cauda epididymis but some normal testicular sperm are seen
detached sperm flagellum ( J:265193 )
• ~79% of headless flagella from the cauda epididymis display weak motility
• the capitulum and segmented column are found in the separated tail while the basal plate remains attached to the head




Genotype
MGI:6200791
ht2
Allelic
Composition		 Spatc1lem1Choc/Spatc1l+
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spatc1lem1Choc mutation (0 available); any Spatc1l mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:265193 )
N
• females are fertile
absent sperm flagellum ( J:265193 )
• ~53% of sperm
abnormal sperm head morphology ( J:265193 )
• ~25% of sperm have folded heads
reduced male fertility ( J:265193 )
• reduction in the percentage of pregnant females, average litter size, and fertility rate in crosses to wild-type females compared to wild-type males

cellular
absent sperm flagellum ( J:265193 )
• ~53% of sperm
abnormal sperm head morphology ( J:265193 )
• ~25% of sperm have folded heads




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory