About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spatc1lem1Choc
endonuclease-mediated mutation 1, Chunghee Cho
MGI:6200789
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spatc1lem1Choc/Spatc1lem1Choc involves: C57BL/6J * C57BL/6N MGI:6200790
ht2
 		Spatc1lem1Choc/Spatc1l+ involves: C57BL/6J * C57BL/6N MGI:6200791


Genotype
MGI:6200790
hm1
Allelic
Composition		 Spatc1lem1Choc/Spatc1lem1Choc
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spatc1lem1Choc mutation (0 available); any Spatc1l mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:265193 )
N
• females are fertile
• no significant difference in testis size or testis to body weight ratio, normal appearance and weight of the epididymis, no disruptions in seminiferous tubules
teratozoospermia ( J:265193 )
• detached heads are seen in most cauda epididymal sperm
• no intact sperm are seen in the cauda epididymis but some normal testicular sperm are seen
detached sperm flagellum ( J:265193 )
• ~79% of headless flagella from the cauda epididymis display weak motility
• the capitulum and segmented column are found in the separated tail while the basal plate remains attached to the head
male infertility ( J:265193 )
• males produce vaginal plugs but no offspring in crosses with wild-type females

cellular
teratozoospermia ( J:265193 )
• detached heads are seen in most cauda epididymal sperm
• no intact sperm are seen in the cauda epididymis but some normal testicular sperm are seen
detached sperm flagellum ( J:265193 )
• ~79% of headless flagella from the cauda epididymis display weak motility
• the capitulum and segmented column are found in the separated tail while the basal plate remains attached to the head




Genotype
MGI:6200791
ht2
Allelic
Composition		 Spatc1lem1Choc/Spatc1l+
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spatc1lem1Choc mutation (0 available); any Spatc1l mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:265193 )
N
• females are fertile
absent sperm flagellum ( J:265193 )
• ~53% of sperm
abnormal sperm head morphology ( J:265193 )
• ~25% of sperm have folded heads
reduced male fertility ( J:265193 )
• reduction in the percentage of pregnant females, average litter size, and fertility rate in crosses to wild-type females compared to wild-type males

cellular
absent sperm flagellum ( J:265193 )
• ~53% of sperm
abnormal sperm head morphology ( J:265193 )
• ~25% of sperm have folded heads




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory