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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxo43tm1.1Kald
targeted mutation 1.1, Philipp Kaldis
MGI:6201341
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fbxo43tm1.1Kald/Fbxo43tm1.1Kald
Tg(Stra8-icre)1Reb/0 		involves: 129 * C57BL/6 * FVB/NJ * SJL MGI:6201523
cn2
 		Fbxo43tm1.1Kald/Fbxo43tm1.2Kald
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:6201521


Genotype
MGI:6201523
cn1
Allelic
Composition		 Fbxo43tm1.1Kald/Fbxo43tm1.1Kald
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/NJ * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo43tm1.1Kald mutation (0 available); any Fbxo43 mutation (29 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
arrest of male meiosis ( J:251984 )
• in prophase in meiosis I
increased male germ cell apoptosis ( J:251984 )
• at stage XII (pachytene/diplotene)

cellular
arrest of male meiosis ( J:251984 )
• in prophase in meiosis I
increased male germ cell apoptosis ( J:251984 )
• at stage XII (pachytene/diplotene)




Genotype
MGI:6201521
cn2
Allelic
Composition		 Fbxo43tm1.1Kald/Fbxo43tm1.2Kald
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo43tm1.1Kald mutation (0 available); any Fbxo43 mutation (29 available)
Fbxo43tm1.2Kald mutation (0 available); any Fbxo43 mutation (29 available)
Gt(ROSA)26Sortm1(cre/ERT)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased male germ cell apoptosis ( J:251984 )
• at stage XII (pachytene/diplotene) in tamoxifen-treated mice
male infertility ( J:251984 )
• in tamoxifen-treated mice

cellular
increased male germ cell apoptosis ( J:251984 )
• at stage XII (pachytene/diplotene) in tamoxifen-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory