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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbed6tm1.2Sson
targeted mutation 1.2, Leif Andersson
MGI:6201365
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zbed6tm1.2Sson/Zbed6tm1.2Sson involves: BALB/c * C57BL/6 MGI:6201426
cx2
 		Rr143tm1.1Sson/Rr143+
Zbed6tm1.2Sson/Zbed6tm1.2Sson 		involves: BALB/c * C57BL/6 MGI:6201427


Genotype
MGI:6201426
hm1
Allelic
Composition		 Zbed6tm1.2Sson/Zbed6tm1.2Sson
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbed6tm1.2Sson mutation (1 available); any Zbed6 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased lean body mass ( J:265506 )
• in females
increased body weight ( J:265506 )
• females and males weigh about 15% and 4% more than controls at 20 wks of age
• by 23 wks of age difference in body weight is only significant in females
increased kidney weight ( J:265506 )
increased liver weight ( J:265506 )
• statistically significant in females

homeostasis/metabolism
increased respiratory quotient ( J:265506 )
• higher RER values indicate overall increased reliance on carbohydrates in males but not females

muscle
increased skeletal muscle size ( J:265506 )
• increase in the size of the gastro-gastrocnemius, soleus, tibialis anterior, and extensor digitorum longus muscles in females

liver/biliary system
increased liver weight ( J:265506 )
• statistically significant in females

renal/urinary system




Genotype
MGI:6201427
cx2
Allelic
Composition		 Rr143tm1.1Sson/Rr143+
Zbed6tm1.2Sson/Zbed6tm1.2Sson
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr143tm1.1Sson mutation (0 available); any Rr143 mutation (0 available)
Zbed6tm1.2Sson mutation (1 available); any Zbed6 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased lean body mass ( J:265506 )
• in females
increased body weight ( J:265506 )
increased kidney weight ( J:265506 )
increased liver weight ( J:265506 )
• statistically significant in females

homeostasis/metabolism
increased respiratory quotient ( J:265506 )
• higher RER values indicate overall increased reliance on carbohydrates in males but not females

muscle
increased skeletal muscle size ( J:265506 )
• increase in the size of the gastro-gastrocnemius, soleus, tibialis anterior, and extensor digitorum longus muscles in females with a paternally inherited allele

liver/biliary system
increased liver weight ( J:265506 )
• statistically significant in females

renal/urinary system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory