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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr143tm1.1Sson
targeted mutation 1.1, Leif Andersson
MGI:6201366
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Rr143tm1.1Sson/Rr143+ involves: BALB/c * C57BL/6 MGI:6201428
cx2
 		Rr143tm1.1Sson/Rr143+
Zbed6tm1.2Sson/Zbed6tm1.2Sson 		involves: BALB/c * C57BL/6 MGI:6201427


Genotype
MGI:6201428
ht1
Allelic
Composition		 Rr143tm1.1Sson/Rr143+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased heart weight ( J:265506 )
• statistically significant in females
increased lean body mass ( J:265506 )
• in mice with a paternally inherited mutant allele
increased body weight ( J:265506 )
• mice with a paternally inherited mutant allele weigh about 20% more than controls at 20 wks of age
increased kidney weight ( J:265506 )

muscle
increased skeletal muscle size ( J:265506 )
• increase in the size of the gastro-gastrocnemius, soleus, tibialis anterior, and extensor digitorum longus muscles in males and females with a paternally inherited allele

cardiovascular system
increased heart weight ( J:265506 )
• statistically significant in females

renal/urinary system




Genotype
MGI:6201427
cx2
Allelic
Composition		 Rr143tm1.1Sson/Rr143+
Zbed6tm1.2Sson/Zbed6tm1.2Sson
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr143tm1.1Sson mutation (0 available); any Rr143 mutation (0 available)
Zbed6tm1.2Sson mutation (1 available); any Zbed6 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased lean body mass ( J:265506 )
• in females
increased body weight ( J:265506 )
increased kidney weight ( J:265506 )
increased liver weight ( J:265506 )
• statistically significant in females

homeostasis/metabolism
increased respiratory quotient ( J:265506 )
• higher RER values indicate overall increased reliance on carbohydrates in males but not females

muscle
increased skeletal muscle size ( J:265506 )
• increase in the size of the gastro-gastrocnemius, soleus, tibialis anterior, and extensor digitorum longus muscles in females with a paternally inherited allele

liver/biliary system
increased liver weight ( J:265506 )
• statistically significant in females

renal/urinary system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory