Phenotypes associated with this allele

• Allele Symbol: Slc9a9^{tm2c(KOMP)Wtsi}
• Allele Name: targeted mutation 2c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6201439
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Slc9a9^tm2c(KOMP)Wtsi/Slc9a9^tm2c(KOMP)Wtsi Tg(Nes-cre)1Kln/0	involves: C57BL/6 * C57BL/6N * SJL	MGI:6201594
cn2	Slc9a9^tm2c(KOMP)Wtsi/Slc9a9^+ Tg(Nes-cre)1Kln/0	involves: C57BL/6 * C57BL/6N * SJL	MGI:6201595

Genotype
MGI:6201594

cn1

• Allelic Composition: Slc9a9^{tm2c(KOMP)Wtsi}/Slc9a9^{tm2c(KOMP)Wtsi}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:258593 )

N • no gross defects in motor behavior

abnormal habituation ( J:258593 )

• adults fail to habituate to a novel mouse upon repeated exposures

• however, adults spend more time with a novel mouse than a novel object or familiar mouse suggesting similar interest in social interactions compared to controls

abnormal olfactory behavior ( J:258593 )

• fail to respond differently to non-social (food), social, and aversive scents unlike controls

• however, mice are similar to wild-type controls in the ability to find a buried cookie indicating the absence of a gross defect in olfaction

abnormal allogrooming behavior ( J:258593 )

• reduced in juveniles

increased stereotypic behavior ( J:258593 )

• increase in repetitive digging behavior

abnormal social/conspecific interaction behavior ( J:258593 )

• reduced in juveniles

abnormal social investigation ( J:258593 )

• reduced in juveniles

abnormal social recognition ( J:258593 )

• impaired in adults

abnormal social play behavior ( J:258593 )

• juveniles display reduced play soliciting

growth/size/body

decreased body weight ( J:258593 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:258593

Genotype
MGI:6201595

cn2

• Allelic Composition: Slc9a9^{tm2c(KOMP)Wtsi}/Slc9a9⁺; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * SJL

behavior/neurological

abnormal social investigation ( J:258593 )

• reduced in juveniles

abnormal social play behavior ( J:258593 )

• juveniles display reduced play soliciting