Analysis Tools
mortality/aging
|
• most mice die between 4 and 6 months of age
• more than 50% of females survive to 5 months of age, approximately 1 month longer than males, indicating better survival for females
• treatment with rapamycin from P10 to P60 improves survival, with female rapamycin-treated mice having a median survival of about 7 months and male rapamycin-treated mice 6 months
• enhanced rapamycin treatment (extended duration) improves lifespan even more to a median survival of about 8 months
|
renal/urinary system
|
• mice show increased proliferation in renal epithelia
• rapamycin treatment suppresses the increased proliferation in renal epithelia
|
|
• by 4 months of age, normal parenchyma is almost completely lost in the kidney
|
kidney cyst
(
J:265516
)
|
• mice develop severe cysts in the kidneys
• renal cysts derive from all nephronic segments of the kidney
• renal cytogenesis is more severe in males than females
• treatment with rapamycin from P10 to P60 reduces growth of renal cysts, with treatment response better in females than males
• enhanced rapamycin treatment (extended duration) reduces renal cyst growth even more
|
|
• mice exhibit a larger kidney/body weight ratio by P15
|
endocrine/exocrine glands
|
• cysts in the pancreas are seen starting at 4 months of age
|
liver/biliary system
liver cyst
(
J:265516
)
|
• cysts in liver are seen starting at 2 months of age with the cystic liver worsening rapidly with age
• however, the liver/body weight ratio and alanine aminotransferase levels are not different from wild-type
|
homeostasis/metabolism
|
• mice show a higher creatinine level at 1 month of age
• creatinine levels are more elevated in males than in females at 4 months of age
• treatment with rapamycin improves creatinine levels but not completely to normal levels
• enhanced rapamycin treatment improves creatinine levels further
|
|
• mice show a higher blood urea nitrogen level at 2 months of age
• blood urea nitrogen levels are more elevated in males than in females at 4 months of age
• treatment with rapamycin or enhanced rapamycin (extended duration) improves BUN levels to normal
|
cellular
|
• mice show increased proliferation in renal epithelia
• rapamycin treatment suppresses the increased proliferation in renal epithelia
|
growth/size/body
|
• cysts in the pancreas are seen starting at 4 months of age
|
kidney cyst
(
J:265516
)
|
• mice develop severe cysts in the kidneys
• renal cysts derive from all nephronic segments of the kidney
• renal cytogenesis is more severe in males than females
• treatment with rapamycin from P10 to P60 reduces growth of renal cysts, with treatment response better in females than males
• enhanced rapamycin treatment (extended duration) reduces renal cyst growth even more
|
liver cyst
(
J:265516
)
|
• cysts in liver are seen starting at 2 months of age with the cystic liver worsening rapidly with age
• however, the liver/body weight ratio and alanine aminotransferase levels are not different from wild-type
|
|
• mice exhibit a larger kidney/body weight ratio by P15
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autosomal dominant polycystic kidney disease | DOID:898 | J:265516 | ||
