Phenotypes associated with this allele

• Allele Symbol: Trp53^tm1.1Hwan
• Allele Name: targeted mutation 1.1, Paul M Hwang
• Allele ID: MGI:6202103
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1.1Hwan/Trp53^tm1.1Hwan	involves: C57BL/6 * C57BL/6N	MGI:6246602
ht2	Trp53^tm1.1Hwan/Trp53^+	involves: C57BL/6 * C57BL/6N	MGI:6246603

Genotype
MGI:6246602

hm1

• Allelic Composition: Trp53^tm1.1Hwan/Trp53^tm1.1Hwan
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:265556 )

• mice show increased susceptibility to diethylnitrosamine (DEN)-induced liver carcinogenesis, with mice showing an increase in the number and size of tumors on the surface of the liver and liver tumors showing increased incidence of carcinomas

• however, de novo tumorigenesis is not significantly increased in mutants compared to wild-type mice

mortality/aging

lethality, incomplete penetrance ( J:265556 )

♀ • a trend of lower than expected number of female homozygous pups is seen

cellular

increased cellular sensitivity to DNA damaging agents ( J:265556 )

• mice exposed to DEN exhibit increased DNA damage but slightly decreased apoptosis and cell-cycle arrest in the liver

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:265556 )

• mice show increased susceptibility to diethylnitrosamine (DEN)-induced liver carcinogenesis, with mice showing an increase in the number and size of tumors on the surface of the liver and liver tumors showing increased incidence of carcinomas

• however, de novo tumorigenesis is not significantly increased in mutants compared to wild-type mice

Genotype
MGI:6246603

ht2

• Allelic Composition: Trp53^tm1.1Hwan/Trp53⁺
• Genetic Background: involves: C57BL/6 * C57BL/6N

neoplasm

increased incidence of tumors by chemical induction ( J:265556 )

• mice show increased susceptibility to diethylnitrosamine (DEN)-induced liver carcinogenesis, with mice showing an increase in the number and size of tumors on the surface of the liver

• however, incidence of carcinomas in the liver is not different from wild-type

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:265556 )

• mice show increased susceptibility to diethylnitrosamine (DEN)-induced liver carcinogenesis, with mice showing an increase in the number and size of tumors on the surface of the liver

• however, incidence of carcinomas in the liver is not different from wild-type