Phenotypes associated with this allele

• Allele Symbol: Vrtn^em#Lhhg
• Allele Name: endonuclease-mediated mutation, Lusheng Huang
• Allele ID: MGI:6202694
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vrtn^em#Lhhg/Vrtn^em#Lhhg	involves: C57BL/6	MGI:6202720
ht2	Vrtn^em#Lhhg/Vrtn^+	involves: C57BL/6	MGI:6202721

Genotype
MGI:6202720

hm1

• Allelic Composition: Vrtn^em#Lhhg/Vrtn^em#Lhhg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:264400 )

• mice die between E10.5 and E11.5

embryo

failure of initiation of embryo turning ( J:264400 )

embryonic growth retardation ( J:264400 )

• at E9.5

• however, development is normal at E8.5

abnormal neural tube morphology ( J:264400 )

• at E9.5 and E10.5

impaired somite development ( J:264400 )

• fewer somites

growth/size/body

embryonic growth retardation ( J:264400 )

• at E9.5

• however, development is normal at E8.5

cardiovascular system

abnormal heart tube morphology ( J:264400 )

• at E9.5 and E10.5

nervous system

abnormal neural tube morphology ( J:264400 )

• at E9.5 and E10.5

Genotype
MGI:6202721

ht2

• Allelic Composition: Vrtn^em#Lhhg/Vrtn⁺
• Genetic Background: involves: C57BL/6

skeleton

decreased rib number ( J:264400 )

• missing rib in 9 of 26 mice from the last thoracic element on one side (randomly on the right or left)

decreased thoracic vertebrae number ( J:264400 )

• one less thoracic vertebrae in 7 of 26 mice

kyphosis ( J:264400 )

• prominent at 2 months of age in 16 of 26 mice