Phenotypes associated with this allele

• Allele Symbol: Slc30a2^tm1Kgna
• Allele Name: targeted mutation 1, Keigo Nishida
• Allele ID: MGI:6202882
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc30a2^tm1Kgna/Slc30a2^tm1Kgna	involves: 129 * C57BL/6	MGI:6202901

Genotype
MGI:6202901

hm1

• Allelic Composition: Slc30a2^tm1Kgna/Slc30a2^tm1Kgna
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

decreased mammary gland epithelial cell proliferation ( J:264481 )

• in nulliparous mammary glands

increased mammary gland epithelial cell proliferation ( J:264481 )

• in lactating mammary glands

abnormal mammary gland development ( J:264481 )

• impaired growth and development

• fewer duct cells due to reduced proliferation and increased apoptosis

• however, alveolar bud formation is normal

abnormal mammary gland growth during lactation ( J:264481 )

• reduced lobuloalveolar expansion during lactation

abnormal mammary gland epithelium morphology ( J:264481 )

• defective subcellular organization with loss of distinct cell-cell junctions, numerous pseudolumina, disturbed apical membrane, swollen mitochondria, fragmented endoplasmic reticulum, defective secretory vesicles consisting of improperly packaged casein micelles, and lipid droplets that fail to fuse for secretion

abnormal mammary gland duct morphology ( J:264481 )

• reduced ductal length and lateral branching

abnormal branching of the mammary ductal tree ( J:264481 )

• reduced primary and secondary duct invasion and expansion into the fat pad

abnormal mammary gland luminal epithelium morphology ( J:264481 )

• irregular shaped and narrow distention of alveolar lumen

hypolactation ( J:264481 )

• during early and peak lactation periods resulting in reduced litter survival

increased mammary gland apoptosis ( J:264481 )

• in nulliparous mammary glands

• in lactating mammary glands

homeostasis/metabolism

abnormal zinc homeostasis ( J:264481 )

• increased in the mammary gland during lactation

• reduced milk zinc concentrations

• however, plasma and liver levels are normal

immune system

abnormal macrophage physiology ( J:264481 )

• abnormally activated in the mammary gland

cellular

decreased mammary gland epithelial cell proliferation ( J:264481 )

• in nulliparous mammary glands

increased mammary gland epithelial cell proliferation ( J:264481 )

• in lactating mammary glands

maternal effect ( J:264481 )

• reduced litter survival due to impaired lactation

endocrine/exocrine glands

decreased mammary gland epithelial cell proliferation ( J:264481 )

• in nulliparous mammary glands

increased mammary gland epithelial cell proliferation ( J:264481 )

• in lactating mammary glands

abnormal mammary gland development ( J:264481 )

• impaired growth and development

• fewer duct cells due to reduced proliferation and increased apoptosis

• however, alveolar bud formation is normal

abnormal mammary gland growth during lactation ( J:264481 )

• reduced lobuloalveolar expansion during lactation

abnormal mammary gland epithelium morphology ( J:264481 )

• defective subcellular organization with loss of distinct cell-cell junctions, numerous pseudolumina, disturbed apical membrane, swollen mitochondria, fragmented endoplasmic reticulum, defective secretory vesicles consisting of improperly packaged casein micelles, and lipid droplets that fail to fuse for secretion

abnormal mammary gland duct morphology ( J:264481 )

• reduced ductal length and lateral branching

abnormal branching of the mammary ductal tree ( J:264481 )

• reduced primary and secondary duct invasion and expansion into the fat pad

abnormal mammary gland luminal epithelium morphology ( J:264481 )

• irregular shaped and narrow distention of alveolar lumen

hypolactation ( J:264481 )

• during early and peak lactation periods resulting in reduced litter survival

increased mammary gland apoptosis ( J:264481 )

• in nulliparous mammary glands

• in lactating mammary glands

hematopoietic system

abnormal macrophage physiology ( J:264481 )

• abnormally activated in the mammary gland