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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
P2rx7tm1.1(P2RX7)Jde
targeted mutation 1.1, Jan Deussing
MGI:6203041
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
P2rx7tm1.1(P2RX7)Jde/P2rx7tm2.1(P2RX7*)Jde involves: 129S2/SvPas * C57BL/6J MGI:6331111


Genotype
MGI:6331111
ht1
Allelic
Composition
P2rx7tm1.1(P2RX7)Jde/P2rx7tm2.1(P2RX7*)Jde
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx7tm1.1(P2RX7)Jde mutation (0 available); any P2rx7 mutation (54 available)
P2rx7tm2.1(P2RX7*)Jde mutation (0 available); any P2rx7 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• no differences in emotional behavior are seen in the open field test, elevated plus maze, dark-light box test or forced swim test
• mice subjected to chronic social defeat stress for 3 weeks show similar physiological and neuroendocrine changes as control mice
• mice exhibit altered sleep and attenuated quality of sleep
• only a small amount of deep non-REM sleep is detected in mice, suggesting a shallower non-REM sleep stage
• slow-wave activity during non-REM sleep, measuring the depth of non-REM sleep, is lower
• mice show a higher number of episode entries to REM sleep during the light period, suggesting a stronger drive toward REM sleep and more fragmented sleep cycles
• mice show a higher number of episode entries to REM sleep during the light period, suggesting a stronger drive toward REM sleep and more fragmented sleep cycles

cellular
• mixed primary hippocampal cells show attenuated calcium uptake in response to BzATP stimulation





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory