All Phenotypes Cep57<em2Jvd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cep57^em2Jvd
endonuclease-mediated mutation 2, Jan M A van Deursen
MGI:6208812

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cep57^em2Jvd/Cep57^em2Jvd	involves: FVB/N	MGI:6208868
ht2	Cep57^em2Jvd/Cep57⁺	involves: FVB/N	MGI:6208870
ht3	Cep57^em1Jvd/Cep57^em2Jvd	involves: 129 * C57BL/6 * FVB/N	MGI:6208871

Allelic Composition	Cep57^em2Jvd/Cep57^em2Jvd
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cep57^em2Jvd mutation (0 available); any Cep57 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:264300 )

• fewer than expected mice are present at E13.5 with no mice alive at E15.5

embryonic lethality, incomplete penetrance ( J:264300 )

• fewer than expected mice are present at E13.5

Allelic Composition	Cep57^em2Jvd/Cep57⁺
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cep57^em2Jvd mutation (0 available); any Cep57 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:264300 )

• at 16 months of age

increased lung adenoma incidence ( J:264300 )

cellular

aneuploidy ( J:264300 )

• in splenocytes at 5 months of age

respiratory system

increased lung adenoma incidence ( J:264300 )

Allelic Composition	Cep57^em1Jvd/Cep57^em2Jvd
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cep57^em1Jvd mutation (0 available); any Cep57 mutation (36 available)
Cep57^em2Jvd mutation (0 available); any Cep57 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell morphology ( J:264300 )

• some mouse embryonic fibroblasts exhibit supernumerary centrioles at metaphase due to improper timing of centriole disengagement in mitosis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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