Phenotypes associated with this allele

• Allele Symbol: Nup205^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6209645
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nup205^em1(IMPC)J/Nup205^em1(IMPC)J	C57BL/6NJ-Nup205^em1(IMPC)J/Mmjax	MGI:6492994
ht2	Nup205^em1(IMPC)J/Nup205^+	C57BL/6NJ-Nup205^em1(IMPC)J/Mmjax	MGI:6492993

Genotype
MGI:6492994

hm1

• Allelic Composition: Nup205^em1(IMPC)J/Nup205^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Nup205^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Nup205

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Nup205^em1(IMPC)J/Nup205^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts fail to hatch from the zona pellucida and are dead after 72hr in vitro.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, blastocysts fail to hatch from the zona pellucida and are dead after 3 days in culture

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality before implantation, complete penetrance ( J:279207 )

• early blastocysts are present at E3.5 (15% versus 25%, n=20); no homozygous embryos or excess resorption sites are observed at E7.5

Genotype
MGI:6492993

ht2

• Allelic Composition: Nup205^em1(IMPC)J/Nup205⁺
• Genetic Background: C57BL/6NJ-Nup205^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Nup205

adipose tissue

increased total body fat amount ( J:211773 )

♂

IMPC - JAX

growth/size/body

decreased lean body mass ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

♂

IMPC - JAX