Phenotypes associated with this allele

• Allele Symbol: Actb^em1Erv
• Allele Name: endonuclease-mediated mutation 1, James Ervasti
• Allele ID: MGI:6209780
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Actb^em1Erv/Actb^em1Erv	involves: C57BL/6	MGI:6241369

Genotype
MGI:6241369

hm1

• Allelic Composition: Actb^em1Erv/Actb^em1Erv
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal outer hair cell stereociliary bundle morphology ( J:265862 )

• by 6 months of age some OHC stereocilia bundles are missing

short outer hair cell stereocilia ( J:265862 )

• by 6 months of age stereocilia in outer hair cell (OHC) are shorter and fewer in number

decreased outer hair cell stereocilia number ( J:265862 )

• by 6 months of age stereocilia in outer hair cell (OHC) are shorter and fewer in number

increased susceptibility to age-related hearing loss ( J:265862 )

• some hearing loss in 6 week old mice at 32 kHz frequency

• by 6 months of age, elevated ABR thresholds at and above 16 kHz

impaired hearing ( J:265862 )

• progressive high frequency hearing loss

muscle

muscle phenotype ( J:265862 )

N

nervous system

abnormal outer hair cell stereociliary bundle morphology ( J:265862 )

• by 6 months of age some OHC stereocilia bundles are missing

short outer hair cell stereocilia ( J:265862 )

• by 6 months of age stereocilia in outer hair cell (OHC) are shorter and fewer in number

decreased outer hair cell stereocilia number ( J:265862 )

• by 6 months of age stereocilia in outer hair cell (OHC) are shorter and fewer in number