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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polr3aGt(LG04)Osb
gene trap (LG04), Research Institute for Microbial Diseases, Osaka University
MGI:6214817
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Polr3aGt(LG04)Osb/Polr3aGt(LG04)Osb B6;D2-Polr3aGt(LG04)Osb/OsbRbrc MGI:6214846
ht2
 		Polr3aGt(LG04)Osb/Polr3atm1Bebr involves: C57BL/6 * C57BL/6J * DBA/2 MGI:6214847


Genotype
MGI:6214846
hm1
Allelic
Composition		 Polr3aGt(LG04)Osb/Polr3aGt(LG04)Osb
Genetic
Background		 B6;D2-Polr3aGt(LG04)Osb/OsbRbrc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr3aGt(LG04)Osb mutation (0 available); any Polr3a mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6214847
ht2
Allelic
Composition		 Polr3aGt(LG04)Osb/Polr3atm1Bebr
Genetic
Background		 involves: C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr3aGt(LG04)Osb mutation (0 available); any Polr3a mutation (70 available)
Polr3atm1Bebr mutation (0 available); any Polr3a mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:250577 )
• mice exhibit a small, but significant, reduction in their back paw limb width at 270 days of age; this trend was seen at 365 days of age but is insignificant
• however, mice do not display other motor dysfunction at 1 year of age

nervous system
nervous system phenotype ( J:250577 )
N
• mice exhibit normal and complete myelination in the brain and cerebellum at 90 and 365 days of age and cerebellar morphology and Purkinje cell numbers are normal in 1 year old mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT hypomyelinating leukodystrophy 7 DOID:0060794 OMIM:607694
 J:250577




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory