Phenotypes associated with this allele

• Allele Symbol: Wnk4^tm3.1Suc
• Allele Name: targeted mutation 3.1, Shinchi Uchida
• Allele ID: MGI:6214838
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnk4^tm3.1Suc/Wnk4^tm3.1Suc	involves: 129S4/SvJae * C57BL/6J	MGI:6214840

Genotype
MGI:6214840

hm1

• Allelic Composition: Wnk4^tm3.1Suc/Wnk4^tm3.1Suc
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased systemic arterial systolic blood pressure ( J:241978 )

♂ • mice on a low-salt diet exhibit lower systolic blood pressure than controls

♂ • however, blood pressure is normal when mice are fed a normal or high-sodium diet

homeostasis/metabolism

alkalemia ( J:241978 )

• mice exhibit higher plasma pH

decreased circulating sodium level ( J:241978 )

• mice exhibit lower plasma sodium levels

• however, plasma potassium levels are normal

decreased circulating chloride level ( J:241978 )

• mice exhibit lower plasma chloride levels