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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd4em1Litt
endonuclease-mediated mutation 1, Dan R Littman
MGI:6220669
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd4em1Litt/Cd4em1Litt involves: C57BL/6J MGI:7439996
cx2
 		Cd4em1Litt/Cd4em1Litt
Rr386em1Pdi/Rr386em1Pdi 		involves: C57BL/6J MGI:7439995


Genotype
MGI:7439996
hm1
Allelic
Composition		 Cd4em1Litt/Cd4em1Litt
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4em1Litt mutation (1 available); any Cd4 mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:333574 )
N
• normal reaction to Leishmania major (L. major) infection




Genotype
MGI:7439995
cx2
Allelic
Composition		 Cd4em1Litt/Cd4em1Litt
Rr386em1Pdi/Rr386em1Pdi
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4em1Litt mutation (1 available); any Cd4 mutation (85 available)
Rr386em1Pdi mutation (0 available); any Rr386 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T helper 1 cell number ( J:333574 )
• lower frequency and number of Tbet+ CD11a-hi CD44+ helper T cells in draining lymph nodes (dLNs) 28 days after infection with Leishmania major (L. major)
abnormal lymphocyte activation involved in immune response ( J:333574 )
• delayed swelling of cutaneous infection point after infection with Leishmania major (L. major)
• increased parasitic burden 28 and 54 days after infection with Leishmania major (L. major)
• Leishmania major (L. major) infection lesions resolved in normal time
• normal parasitic burden 9 days after infection with Leishmania major (L. major)

immune system
immune system phenotype ( J:333574 )
N
• normal proportions of CD11a-hi CD49d+ and CD11a-hi CD44+ T cells in draining lymph nodes (dLNs) 9 days after infection with Leishmania major (L. major)
• normal frequency of GATA3+ CD11a-hi CD44+ T cells in draining lymph nodes (dLNs) 28 days after infection with Leishmania major (L. major)
• normal absolute T cell numbers in draining lymph nodes (dLNs) 28 days after infection with Leishmania major (L. major)
decreased T helper 1 cell number ( J:333574 )
• lower frequency and number of Tbet+ CD11a-hi CD44+ helper T cells in draining lymph nodes (dLNs) 28 days after infection with Leishmania major (L. major)
abnormal lymphocyte activation involved in immune response ( J:333574 )
• delayed swelling of cutaneous infection point after infection with Leishmania major (L. major)
• increased parasitic burden 28 and 54 days after infection with Leishmania major (L. major)
• Leishmania major (L. major) infection lesions resolved in normal time
• normal parasitic burden 9 days after infection with Leishmania major (L. major)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory