Analysis Tools
growth/size/body
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• mice fed a high-fat diet starting at 8 weeks of age gain less weight than wild-type mice fed the same diet, have smaller size and mass of visceral fat-pads, and have smaller adipocytes
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adipose tissue
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• size of adipocytes from mice fed a high-fat diet is smaller than of wild-type adipocytes
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• mice fed a high-fat diet exhibit smaller size and mass of visceral fat-pads than in wild-type mice fed the same diet
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hematopoietic system
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• mice exhibit absence of invariant natural killer T (iNKT) cells in the thymus, the spleen and liver
• however, the TCRalpha repertoire is similar to wild-type and developmental stages of thymocytes show no differences from wild-type
• mice show no differences in frequencies of type 2 NKT cells, regulatory T cells, or mucosal-associated invariant T (MAIT) cells in the thymus, or in other immune cell types in the spleen including CD4/8 alpha-betaT cells, gamma-delta T cells, B cells, NK cells, conventional dendritic cells, plasmacytoid dendritic cells, macrophages or granulocytes
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homeostasis/metabolism
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• mice fed a high-fat diet starting at 8 weeks of age gain less weight than wild-type mice fed the same diet, have smaller size and mass of visceral fat-pads, and have smaller adipocytes
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• mice fed a high-fat diet show reduced fasting blood glucose levels compared to wild-type mice fed this diet
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• following injection of glucose, mutant mice fed a high-fat diet that become obese show improved glucose tolerance compared to wild-type mice
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• mice fed a high-fat diet do not exhibit insulin resistance during insulin tolerance tests (ITT) as is seen in wild-type mice fed this diet, with mice showing reduced glucose levels during ITT
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immune system
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• mice exhibit absence of invariant natural killer T (iNKT) cells in the thymus, the spleen and liver
• however, the TCRalpha repertoire is similar to wild-type and developmental stages of thymocytes show no differences from wild-type
• mice show no differences in frequencies of type 2 NKT cells, regulatory T cells, or mucosal-associated invariant T (MAIT) cells in the thymus, or in other immune cell types in the spleen including CD4/8 alpha-betaT cells, gamma-delta T cells, B cells, NK cells, conventional dendritic cells, plasmacytoid dendritic cells, macrophages or granulocytes
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• mice exhibit an absence of cytokine production after alpha-GalCer stimulation, with no production of GM-CSF, IFN-gamma, IL-4, IL-10, IL-13, and IL-17A compared to wild-type mice
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liver/biliary system
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• livers of mice fed a high-fat diet contain less fat deposits compared to wild-type livers of mice fed the same diet
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