Phenotypes associated with this allele

• Allele Symbol: Hectd3^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genomics
• Allele ID: MGI:6256423
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hectd3^tm1Lex/Hectd3^tm1Lex	FVB.129S5(B6)-Hectd3^tm1Lex	MGI:6256436

Genotype
MGI:6256436

hm1

• Allelic Composition: Hectd3^tm1Lex/Hectd3^tm1Lex
• Genetic Background: FVB.129S5(B6)-Hectd3^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:266602 )

• following Francisella novicida infection

immune system

decreased circulating interferon-beta level ( J:266602 )

• following Francisella novicida infection

decreased circulating interleukin-1 beta level ( J:266602 )

• following Francisella novicida infection

decreased circulating interleukin-6 level ( J:266602 )

• following Francisella novicida infection

decreased circulating tumor necrosis factor level ( J:266602 )

• following Francisella novicida infection

decreased susceptibility to bacterial infection ( J:266602 )

• following intranasal Francisella novicida infection, mice exhibit less weight loss, decreased bacterial burden in the spleen, liver and lung, inflammatory cytokines (TNFA, IL6, IL1B and IFNB) in the peripheral blood, reduced dissemination through bacteria-carrying cells due to suppression of intracellular bacterial replication and survival beyond day 10 compared with wild-type mice

• following intranasal Mycobacterium and Listeria infection, mice exhibit resistant to with lower bacterial burden, weight loss and cell death

• however, response to intraperitoneal infection with Mycobacterium exhibit normal body loss and bacterial burden

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:266602 )

• following Francisella novicida infection

homeostasis/metabolism

decreased circulating interferon-beta level ( J:266602 )

• following Francisella novicida infection

decreased circulating interleukin-1 beta level ( J:266602 )

• following Francisella novicida infection

decreased circulating interleukin-6 level ( J:266602 )

• following Francisella novicida infection

decreased circulating tumor necrosis factor level ( J:266602 )

• following Francisella novicida infection