Phenotypes associated with this allele

• Allele Symbol: Usp34^em1Qyn
• Allele Name: endonuclease-mediated mutation 1, Quan Yuan
• Allele ID: MGI:6256462
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Usp34^em1Qyn/Usp34^em1Qyn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: C57BL/6J * CD-1	MGI:6256537
cn2	Tg(Prrx1-cre)1Cjt/0 Usp34^em1Qyn/Usp34^em1Qyn	involves: C57BL/6J * SJL/J	MGI:6256535

Genotype
MGI:6256537

cn1

• Allelic Composition: Usp34^em1Qyn/Usp34^em1Qyn; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased bone mineral density of femur ( J:266454 )

decreased volumetric bone mineral density ( J:266454 )

decreased osteoblast cell number ( J:266454 )

decreased bone trabecula number ( J:266454 )

increased bone trabecular spacing ( J:266454 )

decreased bone mineralization ( J:266454 )

decreased bone ossification ( J:266454 )

Genotype
MGI:6256535

cn2

• Allelic Composition: Tg(Prrx1-cre)1Cjt/0; Usp34^em1Qyn/Usp34^em1Qyn
• Genetic Background: involves: C57BL/6J * SJL/J

skeleton

abnormal bone healing ( J:266454 )

• slowed healing that never achieves comparable healing as in wild-type mice after fracture with reduced trabecular bone volume to trabecular volume, diminished trabeculae number and trabecular thickness, and a large amount of callus cartilage

• drilled holes are only partially filled after 2 weeks compared to complete bridging in control mice with reduced bone mineral density and bone volume to trabecular volume

decreased bone mineral density of femur ( J:266454 )

decreased volumetric bone mineral density ( J:266454 )

decreased osteoblast cell number ( J:266454 )

decreased bone trabecula number ( J:266454 )

increased bone trabecular spacing ( J:266454 )

decreased trabecular bone thickness ( J:266454 )

decreased bone mineralization ( J:266454 )

decreased bone ossification ( J:266454 )

homeostasis/metabolism

abnormal bone healing ( J:266454 )

• slowed healing that never achieves comparable healing as in wild-type mice after fracture with reduced trabecular bone volume to trabecular volume, diminished trabeculae number and trabecular thickness, and a large amount of callus cartilage

• drilled holes are only partially filled after 2 weeks compared to complete bridging in control mice with reduced bone mineral density and bone volume to trabecular volume