Phenotypes associated with this allele

• Allele Symbol: Trpv4^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6256763
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Trpv4^tm1c(KOMP)Wtsi/Trpv4^tm1c(KOMP)Wtsi Tg(GFAP-cre)25Mes/0	involves: C57BL/6J * C57BL/6N * FVB/N	MGI:6256831

Genotype
MGI:6256831

cn1

• Allelic Composition: Trpv4^{tm1c(KOMP)Wtsi}/Trpv4^{tm1c(KOMP)Wtsi}; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal response to injury ( J:266383 )

• after region-specific injection of hyaluronic acid to induce acute retinal detachment (RD), Mueller cells exhibit 50% less cell death and fail to exhibit significant mechanical stimuli-evoked current or inward current and HC067047 did not have an inhibitory effect unlike in wild-type Mueller cells

• however, retina subjected to RD exhibit normal gliosis and increased proliferation