Phenotypes associated with this allele

• Allele Symbol: Uqcr10^em1(IMPC)Bay
• Allele Name: endonuclease-mediated mutation 1, Baylor College of Medicine
• Allele ID: MGI:6257426
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Uqcr10^em1(IMPC)Bay/Uqcr10^em1(IMPC)Bay	C57BL/6N-Uqcr10^em1(IMPC)Bay/Mmucd	MGI:7716882

Genotype
MGI:7716882

hm1

• Allelic Composition: Uqcr10^em1(IMPC)Bay/Uqcr10^em1(IMPC)Bay
• Genetic Background: C57BL/6N-Uqcr10^em1(IMPC)Bay/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Uqcr10^em1(IMPC)Bay/Uqcr10^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos show severe developmental delay presenting as a small egg cylinder and poorly organized extraembryonic tissues.

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are present in Mendelian ratios at E7.5 (31% versus expected 25%, n=16); no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:279207 )

• no Brachyury (T)-positive cells are present at E7.5

embryonic growth retardation ( J:279207 )

• embryos show a severe developmental delay at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a small egg cylinder is observed at E7.5

failure of primitive streak formation ( J:279207 )

disorganized extraembryonic tissue ( J:279207 )

• extraembryonic tissues are poorly organized at E7.5

growth/size/body

embryonic growth retardation ( J:279207 )

• embryos show a severe developmental delay at E7.5