Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nars1em1(IMPC)Bay endonuclease-mediated mutation 1, Baylor College of Medicine MGI:6257548 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Nars1em1(IMPC)Bay/Nars1em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts do not hatch from the zona pellucida or form outgrowths in culture.
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• blastocyst-like embryos are present in expected Mendelian ratios at E3.5; no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo
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• in vitro, blastocysts fail to hatch from the zona pellucida after 3 days in culture
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• in vitro outgrowth assays show that blastocysts do not hatch or form outgrowths after 3 days in culture
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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