Phenotypes associated with this allele

• Allele Symbol: Etv6^{em1(IMPC)Rbrc}
• Allele Name: endonuclease-mediated mutation 1, RIKEN BioResource Center
• Allele ID: MGI:6257614
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Etv6^em1(IMPC)Rbrc/Etv6^em1(IMPC)Rbrc	C57BL/6NJcl-Etv6^em1(IMPC)Rbrc/Rbrc	MGI:7414879
ht2	Etv6^em1(IMPC)Rbrc/Etv6^+	C57BL/6NJcl-Etv6^em1(IMPC)Rbrc/Rbrc	MGI:7414878

Genotype
MGI:7414879

hm1

• Allelic Composition: Etv6^{em1(IMPC)Rbrc}/Etv6^{em1(IMPC)Rbrc}
• Genetic Background: C57BL/6NJcl-Etv6^{em1(IMPC)Rbrc}/Rbrc

Data Sources

IMPC Data for Etv6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - RBRC

Genotype
MGI:7414878

ht2

• Allelic Composition: Etv6^{em1(IMPC)Rbrc}/Etv6⁺
• Genetic Background: C57BL/6NJcl-Etv6^{em1(IMPC)Rbrc}/Rbrc

Data Sources

IMPC Data for Etv6

cardiovascular system

abnormal heart morphology ( J:211773 )

IMPC - RBRC

increased heart atrium size ( J:211773 )

IMPC - RBRC

abnormal heart shape ( J:211773 )

♂

IMPC - RBRC

abnormal heart weight ( J:211773 )

♀

IMPC - RBRC

enlarged heart ( J:211773 )

IMPC - RBRC

growth/size/body

enlarged heart ( J:211773 )

IMPC - RBRC

increased kidney weight ( J:211773 )

♀

IMPC - RBRC

increased spleen weight ( J:211773 )

♀

IMPC - RBRC

hematopoietic system

increased spleen weight ( J:211773 )

♀

IMPC - RBRC

decreased erythrocyte cell number ( J:211773 )

IMPC - RBRC

thrombocytopenia ( J:211773 )

IMPC - RBRC

increased large unstained cell number ( J:211773 )

IMPC - RBRC

homeostasis/metabolism

increased blood uric acid level ( J:211773 )

♀

IMPC - RBRC

decreased circulating cholesterol level ( J:211773 )

♀

IMPC - RBRC

decreased circulating HDL cholesterol level ( J:211773 )

♀

IMPC - RBRC

decreased circulating calcium level ( J:211773 )

♀

IMPC - RBRC

decreased circulating serum albumin level ( J:211773 )

♀

IMPC - RBRC

decreased circulating total protein level ( J:211773 )

♀

IMPC - RBRC

immune system

increased spleen weight ( J:211773 )

♀

IMPC - RBRC

increased large unstained cell number ( J:211773 )

IMPC - RBRC

liver/biliary system

abnormal liver morphology ( J:211773 )

IMPC - RBRC

small liver ( J:211773 )

IMPC - RBRC

renal/urinary system

increased kidney weight ( J:211773 )

♀

IMPC - RBRC

skeleton

decreased bone mineral density ( J:211773 )

♀

IMPC - RBRC