Phenotypes associated with this allele

• Allele Symbol: Tpo^em1(IMPC)H
• Allele Name: endonuclease-mediated mutation 1, Harwell
• Allele ID: MGI:6257652
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpo^em1(IMPC)H/Tpo^em1(IMPC)H	C57BL/6NTac-Tpo^em1(IMPC)H/H	MGI:6408737
ht2	Tpo^em1(IMPC)H/Tpo^+	C57BL/6NTac-Tpo^em1(IMPC)H/H	MGI:6408736

Genotype
MGI:6408737

hm1

• Allelic Composition: Tpo^em1(IMPC)H/Tpo^em1(IMPC)H
• Genetic Background: C57BL/6NTac-Tpo^em1(IMPC)H/H

Data Sources

IMPC Data for Tpo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - HAR

impaired righting response ( J:211773 )

♂

IMPC - HAR

abnormal startle reflex ( J:211773 )

♂

IMPC - HAR

limb grasping ( J:211773 )

♂

IMPC - HAR

tremors ( J:211773 )

♂

IMPC - HAR

abnormal gait ( J:211773 )

♂

IMPC - HAR

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

♂

IMPC - HAR

increased circulating cholesterol level ( J:211773 )

♂

IMPC - HAR

increased circulating iron level ( J:211773 )

♂

IMPC - HAR

increased circulating alkaline phosphatase level ( J:211773 )

♂

IMPC - HAR

increased circulating aspartate transaminase level ( J:211773 )

♂

IMPC - HAR

integument

abnormal coat/ hair morphology ( J:211773 )

♂

IMPC - HAR

limbs/digits/tail

abnormal forelimb morphology ( J:211773 )

♂

IMPC - HAR

abnormal hindlimb morphology ( J:211773 )

♂

IMPC - HAR

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:6408736

ht2

• Allelic Composition: Tpo^em1(IMPC)H/Tpo⁺
• Genetic Background: C57BL/6NTac-Tpo^em1(IMPC)H/H

Data Sources

IMPC Data for Tpo

hematopoietic system

increased mean platelet volume ( J:211773 )

IMPC - HAR

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

IMPC - HAR

improved glucose tolerance ( J:211773 )

♀

IMPC - HAR