Allele Symbol Allele Name Allele ID |
Atp5f1dem1(IMPC)Bay endonuclease-mediated mutation 1, Baylor College of Medicine MGI:6257672 |
||||||||||||
Summary |
2 genotypes
|
|
|
Data Sources
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Atp5f1dem1(IMPC)Bay/Atp5f1dem1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts fail to hatch from the zona pellucida after 3 days in culture.
• homozygous embryos are present in expected Mendelian ratios at E3.5 and appear as blastocysts; no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo
|
• in vitro, blastocysts fail to hatch from the zona pellucida after 3 days in culture
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|