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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atp5f1dem1(IMPC)Bay
endonuclease-mediated mutation 1, Baylor College of Medicine
MGI:6257672
Summary 2 genotypes


Genotype
MGI:6731251
hm1
Allelic
Composition
Atp5f1dem1(IMPC)Bay/Atp5f1dem1(IMPC)Bay
Genetic
Background
C57BL/6N-Atp5f1dem1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp5f1dem1(IMPC)Bay mutation (1 available); any Atp5f1d mutation (6 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7720270
hm2
Allelic
Composition
Atp5f1dem1(IMPC)Bay/Atp5f1dem1(IMPC)Bay
Genetic
Background
C57BL/6N-Atp5f1dem1(IMPC)Bay/Mmmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp5f1dem1(IMPC)Bay mutation (1 available); any Atp5f1d mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Atp5f1dem1(IMPC)Bay/Atp5f1dem1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts fail to hatch from the zona pellucida after 3 days in culture.

mortality/aging
• homozygous embryos are present in expected Mendelian ratios at E3.5 and appear as blastocysts; no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

embryo
• in vitro, blastocysts fail to hatch from the zona pellucida after 3 days in culture





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory