Analysis Tools|
Allele Symbol Allele Name Allele ID |
Efl1em1(IMPC)Bay endonuclease-mediated mutation 1, Baylor College of Medicine MGI:6257755 |
||||||||||||
| Summary |
2 genotypes
|
|
|
Data Sources
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Efl1em1(IMPC)Bay/Efl1em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos show severe developmental delay, poorly organized extraembryonic tissues, and no gastrulation.
|
• although homozygous embryos are present in expected Mendelian ratios at E7.5, none are recovered at E9.5
|
|
• embryos fail to initiate gastrulation; no Brachyury (T)-positive cells are present at E7.5
|
|
• embryos show a severe developmental delay at E7.5
|
|
• a small egg cylinder is observed at E7.5
|
|
• no Brachyury (T)-positive cells are present at E7.5
|
|
• extraembryonic tissues are poorly organized at E7.5
|
|
• embryos show a severe developmental delay at E7.5
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
