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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc7a7em1(IMPC)Bay
endonuclease-mediated mutation 1, Baylor College of Medicine
MGI:6257790
Summary 4 genotypes


Genotype
MGI:7380582
hm1
Allelic
Composition		 Slc7a7em1(IMPC)Bay/Slc7a7em1(IMPC)Bay
Genetic
Background		 C57BL/6N-Slc7a7em1(IMPC)Bay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc7a7em1(IMPC)Bay mutation (1 available); any Slc7a7 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:293773 )
• no homozygous mice are found at P13

nervous system
hydrocephaly ( J:293773 )
• in 8 of 8 mice at E18.5

cardiovascular system
ventricular septal defect ( J:293773 )
• in 1 of 8 mice at E18.5
cardiac hypertrophy ( J:293773 )
• ventricular hypertrophy in 1 of 8 mice at E18.5

craniofacial
cleft palate ( J:293773 )
• in 2 of 8 mice at E18.5
short snout ( J:293773 )
• in 2 of 8 mice at E18.5

growth/size/body
cardiac hypertrophy ( J:293773 )
• ventricular hypertrophy in 1 of 8 mice at E18.5
cleft palate ( J:293773 )
• in 2 of 8 mice at E18.5
short snout ( J:293773 )
• in 2 of 8 mice at E18.5
decreased fetal size ( J:293773 )
• decreased length and volume at E18.5

digestive/alimentary system
cleft palate ( J:293773 )
• in 2 of 8 mice at E18.5




Genotype
MGI:6325180
hm2
Allelic
Composition		 Slc7a7em1(IMPC)Bay/Slc7a7em1(IMPC)Bay
Genetic
Background		 C57BL/6N-Slc7a7em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc7a7em1(IMPC)Bay mutation (1 available); any Slc7a7 mutation (78 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo

growth/size/body
embryonic growth retardation ( J:211773 )
IMPC - BCM
abnormal embryo size ( J:211773 )
IMPC - BCM

mortality/aging




Genotype
MGI:6297219
hm3
Allelic
Composition		 Slc7a7em1(IMPC)Bay/Slc7a7em1(IMPC)Bay
Genetic
Background		 C57BL/6N-Slc7a7em1(IMPC)Bay/Mcmud
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc7a7em1(IMPC)Bay mutation (1 available); any Slc7a7 mutation (78 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo

growth/size/body
abnormal embryo size ( J:211773 )
IMPC - BCM

mortality/aging




Genotype
MGI:6325179
ht4
Allelic
Composition		 Slc7a7em1(IMPC)Bay/Slc7a7+
Genetic
Background		 C57BL/6N-Slc7a7em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc7a7em1(IMPC)Bay mutation (1 available); any Slc7a7 mutation (78 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased lean body mass ( J:211773 )
IMPC - BCM




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory